01-03-2025, 02:53 AM
Several factors can influence how Modafinil is metabolized, including:
Genetics – Some individuals have variations in the CYP2C19 enzyme, leading to slower metabolism and prolonged drug effects.
Age – Older adults may metabolize Modafinil more slowly, increasing the risk of prolonged effects and potential side effects.
Liver Function – Impaired liver function can reduce the breakdown of Modafinil, leading to higher plasma concentrations.
Drug Interactions – Modafinil induces the CYP3A4 enzyme, which can accelerate the metabolism of other drugs like oral contraceptives, reducing their effectiveness. Conversely, inhibitors of CYP3A4, such as ketoconazole, can slow Modafinil Modvigil 200 Australia metabolism, increasing its effects and duration.
Genetics – Some individuals have variations in the CYP2C19 enzyme, leading to slower metabolism and prolonged drug effects.
Age – Older adults may metabolize Modafinil more slowly, increasing the risk of prolonged effects and potential side effects.
Liver Function – Impaired liver function can reduce the breakdown of Modafinil, leading to higher plasma concentrations.
Drug Interactions – Modafinil induces the CYP3A4 enzyme, which can accelerate the metabolism of other drugs like oral contraceptives, reducing their effectiveness. Conversely, inhibitors of CYP3A4, such as ketoconazole, can slow Modafinil Modvigil 200 Australia metabolism, increasing its effects and duration.